北京中医药大学学士，美国密西西比大学药学院博士，美国斯克里普斯研究所（The Scripps Research Institute）博士后，斯克里普斯研究所准聘免疫学助教授、课题负责人；2008年全职入职南京大学，任病原生物学教授，负责斯尼斯人wns7788本科生“病原生物学”及斯尼斯人wns7788研究生“医学研究方法及科研伦理简介”课程教学，获2020年度斯尼斯人wns7788优秀教师；开设全校公选新生研讨课，入选新生院2025年度最受欢迎课程。

     主要从事病原生物感染及机理研究，包括中药抗病毒作用物质基础、病原微生物感染机制、病毒载体构建及在生物治疗中的应用等研究。主持美国国立卫生研究院（NIH）课题、中国自然科学基金（NSFC）课题、中国863项目，参与国家重点研发计划、美国NIH项目、基金委创新群体基金项目、国家抗日战争研究专项工程项目等；获美国NIH Research Career Development Award；美国NIH基金ad hoc评委。有关文章在美国科学院学报、美国病毒学学报、美国免疫学学报、核酸研究等主要学术刊物上发表；合著《日军细菌部队卫生防疫研究报告选编》（江苏人民出版社，2025）。

 目前在读研究生来自郑州大学、南京医科大学、中国海洋大学、吉林大学等高校；所指导的硕士、博士研究生毕业后主要在长三角主要高校，包括中国药科大学、南京中医药大学、南京农业大学、苏州大学、杭州师范大学、皖南斯尼斯人wns7788及广西师范大学等高校，及上海、杭州、苏州、成都、深圳等城市就业。

Selected peer-reviewed publications (for full publication record, ORCID ID 0000-0002-3065-1336)

Ruilin Wang, Yuanhui Zhao, Jie Yang, Renjie Luo, Weikang Sun, Mengyu Zhang, Xiangdong Liu, Yayi Hou, Peng Cao, and Erguang Li* Systemic BCG administration induces transcription factor signature in CD4⁺ T cells that cooperates with IL-12 signaling to drive antiviral Th1 differentiation. Vaccine. 2026, 85:128720.

Weikang Sun#, Ke Ren#, Jingjing Li#, Mengyu Zhang, Qishen Jiang, Lingling Wang*, Erguang Li*. Activation of the stress-activated protein kinase JNK in response to herpes simplex virus-1 infection coordinates transition of BRD4 from chromosome association to transcription elongation. J Biological Chemistry. 2025, 301(9):110590.

Weikang Sun#, Mengyu Zhang#, Ruilin Wang#, Jie Yang, Ameena Tur Rasool, Renjie Luo, Xiangdong Liu, Peng Cao*, and Erguang Li*, RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression. Cell and Bioscience. 2025, 15:159.

Weikang Sun, Renjie Luo, Qingwei Qua, Jie Yang, Guang Yang, Lihua Song, Peng Cao*, and Erguang Li* Ellagic acid and metabolite urolithin A suppress HSV-1 infection and brain inflammation by targeting casein kinase CK2. J Agricultural and Food Chemistry. 2025, 73(27):17014-17023.

李尔广、吕晶，《日军细菌部队卫生防疫研究报告选编》，江苏人民出版社，2025，ISBN: 9787214295095.

Yan Cheng, Yuanhui Zhao, Yu Liu, Dongge Xu, Weikang Sun, Mengyu Zhang, Yichi Zhang, Yuqing Miao, Susu He, Yayi Hou, Dwayne G. Stupack*, Erguang Li*. Durable anti-tumor responses using an oncolytic adenovirus armed with decoy resistant IL18 variant. J ImmunoTherapy of Cancer. 2024, 12:e009716.

 Yan Cheng, Yu Liu, Dongge Xu, Dan Zhang, Yang Yang, Yuqing Miao, Susu He, Qing Xu*, Erguang Li*. An engineered TNFR1-selective human lymphotoxin-alpha mutant delivered by an oncolytic adenovirus for tumor immunotherapy. BBA-Molecular Basis of Disease, 2024, 1870: 167122.

Zhang MY, Sun WK, You XX, Xu DG, Wang LL, Yang JP, Erguang Li*, and He SS*. LINE-1 repression in Epstein-Barr virus-associated gastric cancer through viral-host genome interaction. Nucleic Acids Research, 2023, 51(10):4867-4880.

Dan Zhang, Yuanhui Zhao, Xiaoxin You, Susu He*, Erguang Li* Repurposing Axl kinase inhibitors for treatment of respiratory syncytial virus infection, AntimicrobAgents Chemotherapy, 2023, 67(3):e0148722.

Zhang D. Zhao YH, Wang LL, You XX, Li JJ, Zhang GH, Hou YY, Wang HW, He SS, and Erguang Li*. Axl mediates resistance to respiratory syncytial virus infection independent of cell attachment. Am J Respiratory Cell Mol Biol, 2022, 67, 227–240.

Wang LL #, Guo HM #, Li JW, Cai XY, He SS, Yang G*, and E Li *. Adenovirus is prevalent in juvenile polyps and correlates with low vitamin D receptor expression. Pediatric Research, 2022, 91:1703–1708.

Wang LL, MY Zhang, JJ Li, G Yang, JW Li, HW Wang, SS He*, and Erguang Li*, HDACi promotes latent adenovirus reactivation from tonsillectomy specimens. J Virol, 2020, 94:e00100-20.

Ren K, Zhang W, Chen X, Ma Y, Dai Y, Fan Y, Hou YY, RX Tan*, and Erguang Li*. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4. PLoS Pathogens2016, 12(10):e1005950.

Ren K, Lv Y, Zhuo Y, Chen C. Shi H, Guo L, Yang G, Hou Y, Tan RX*, Erguang Li*. Suppression of IRG-1 improves immune lung injury after RSV infection by reducing ROS production. J Virol, 2016, 90:7313-7322.

Hui Jiang, Hengfei Shi, Man Sun, Yafeng Wang, Qingzhou Meng, Panpan Guo, Yanlan Cao, Jiong Chen, Xiang Gao, E Li*, and Jianghuai Liu*. PFKFB3-Driven Macrophage Glycolytic Metabolism Is a Crucial Component of Innate Antiviral Defense. J Immunol, 2016, 197:2880-90.

Guo X, Liu T, Shi H, Hou Y, Tan RX and Erguang Li*. NLRC5 induction regulates MHC II expression during RSV infection of airway epithelial cells. J Virol.2015, 89:7636-45.

1.      国家重点研发计划“抗病毒感染性疾病中药的筛选与药效物质基础研究”（子课题，负责南京大学经费270万元，项目编号2023YFC2308200，负责人：曹鹏，总经费1785万元，2023.12-2026.12，在研）

2.     国家自然科学基金面上项目“BRD4调控单纯疱疹病毒感染的分子机制及信号过程研究”（主持，项目编号81871636，到账经费57万，2019-2022，结题）；

3.      科技部-宁夏科技厅牛羊重大传染病快速检测及防治技术（子课题主持，“衣原体感染分子机制研究”，2017BN04，到账经费136万元，2017-2021，结题）；

4.      国家社科基金抗日战争研究专项工程重点项目（子课题主持，细菌战及医学科研伦理教育，2016KZD015，2017-2020，结题，总负责人：张宪文）；